Dosulepin HCl is chemically (E,Z)-3-(dibenzo[b,e]thiepin-11(6H)-ylidene)-N,Ndimethylpropan-1-amine is used to treat depression. The drug is commercially available as tablets for oral administration. In the present work a simple, rapid, accurate, precise, sensitive and economical UV spectrophotometric method has been developed for estimation of dosulepin HCl in tablet dosage form. The λmax of dosulepin HCl was found to be 229 nm. The linearity was observed in concentration range 2-10 µg/ml with correlation coefficient value 0.9996. The proposed method was applied to pharmaceutical formulation and % amount of drug estimated 98.8% was found in good agreement with the label claim. The accuracy of the method was checked by Recovery experiment performed at three different levels i.e., 50%, 100% and 150%. The % recovery was found to be in the range 98.46 – 100.10%. The precision of the method was studied as an intra-day, inter-day variations and repeatability and the % R.S.D value was found to be less than 2 indicate that the method is precise. The above method was a cost-effective quality-control tool for routine analysis of dosulepin HCl in bulk and in pharmaceutical dosage form.
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